10.01 | Family Affair
|  A rising young star is killed in a wreck and her determined stalker claims credit, but the team finds out there's more to this tragedy than meets the eye. |
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| |10.02 | Ghost Town
|  When a porn producer and drug dealer are found dead in a relatively upscale Vegas area, the CSIs focus their investigation on members of the neighborhood. |
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10.03 | Working Stiffs
|  When two office mates plot to rob a casino, their plan ends with the CSIs investigating a murder. |
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| | 10.04 | Coup de Grace
|  When a policeman kills another officer, the CSIs must look to the evidence to determine if the shooting was premeditate or an accident. |
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| 10.05 | Bloodsport
|  An entire college football team comes under investigation when their beloved coach is found murdered in his home.
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|10.07 | The Lost Girl
|  The CSI team helps Langston investigate a prostitution ring that may have harbored a hostage Langston has been looking for in Miami and then New York. |
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| | 10.08 | Lover's Lane
| The CSIs investigate a murder at a bowling alley after a critical piece of evidence is revealed during a bowling tournament.
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| 10.09 | Appendicitement
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When Nick, Greg and Hodges take Henry to celebrate his birthday at a biker bar, they uncover a double homicide and find several suspects still at the bar who may be the murderers.
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| 10.11 | Sin City Blue
| Two beautiful women are murdered in a Las Vegas hotel and the CSIs uncover an unusual killer during their investigation. Meanwhile, Langston continues to hunt "Dr. Jekyll."
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| | 10.12 | Long Ball
| The CSI team delves into the world of professional golf when the body of a legendary player is discovered during a high-profile tournament.
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| 10.13 | Internal Combustion
| The case of two high school students, one dead and one missing, lead the CSIs into the underbelly of streetcar racing and a tangled web of deadly competition.
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| | 10.14 | Unshockable
| When a band member of Rascal Flatts is electrocuted by his own guitar during a concern, the CSI team investigates if it was a case of foul play.
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| 10.15 | Neverland
| When a young boy is found murdered, the CSI team uncovers evidence that may link his death to an old case that recently resurfaced.
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| | 10.16 | The Panty Sniffer
| Catherine and Detective Vartann are thrown together in a hotel room for 24 hours as they stake out a duo making drugs in the room next door. Meanwhile, Nick and Langston work a case that involves a fetish which has become big business in Vegas.
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| 10.17 | Irradiator
| When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.
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| | 10.18 | Field Mice
|  Hodges and Wendy leave the lab behind to lead a group of high school CSI students in training on a field expedition.
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| 10.19 | World's End
|  When a student is discovered murdered at Lindsey's school, the investigation takes a sharp turn when the CSIs uncover an unlikely connection between the boy's death and the atrocities of the past.
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| | 10.20 | Take My Life, Please!
|  A legendary comic from the good old days of Las Vegas is set to reunite with his partner on stage for one night only, until one half the of the famous duo is found dead. |
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10.21 | Lost and Found
|  A mother thought to be grieving for the loss of her family three years ago becomes a suspect in a CSI investigation.
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| | 10.22 | Doctor Who
|  The CSI team must investigate one of their own when Langston is accused by a former colleague of being part of the Dr. Jekyll murders. (Part 1 of 2) |
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| 10.23 | Meat Jekyll
| The CSI's lives are on the line as they close in on the elusive Dr. Jekyll, and more than one member of the team may not live to see his capture.
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CSI Season 10 Episode Guide